Opiates and Clopidogrel Efficacy

Efficacy of Clopidogrel and Clinical Outcome When Clopidogrel Is Coadministered With Atorvastatin and Lansoprazole

This prospective, randomized, nonblind, controlled trial evaluated the effects of clopidogrel on platelet function upon coadministration with atorvastatin and lansoprazole. One hundred four adult patients with non-ST-segment elevated acute coronary syndrome (NSTE-ACS) who underwent percutaneous coronary intervention (PCI) with drug-eluting stent implantation were included. All patients were tre...

Opiates and plasticity.

Opiates are among the most powerful analgesics and pain-relieving agents. However, they are potentially extremely addictive thereby limiting their medical use, making them exceedingly susceptible to abuse and adding to the global drug problem. It is believed that positive memories associated with the pleasurable effects of opiates and negative memories associated with dysphoria during opiate wi...

Paraoxonase 1 Q192R variant and clopidogrel efficacy: fact or fiction?

Clopidogrel, in combination with aspirin, is the standard of care for preventing ischemic cardiovascular events in patients with coronary artery disease, especially those who undergo percutaneous coronary intervention (PCI). Despite its widespread use, significant interindividual variability in clopidogrel response is consistently observed, and recent studies have suggested that as much as 70% ...

Exercise and Endogenous Opiates

Exercise and Endogenous Opiates

The discovery of endogenous opiates in 1975 (1) generated considerable research concerning the effects of exercise on the release of these peptides, particularly on -endorphin, which represents the main focus of this chapter. Previous research considered changes in peripheral blood concentrations induced by different modes of physical activity, influences of training status on the secretion of ...